Absorption and safety of serum-derived bovine immunoglobulin/protein isolate in healthy adults – Dove Medical Press


Audrey L Shaw,1 David W Mathews,1 John E Hinkle,2 Bryon W Petschow,1 Eric M Weaver,3 Christopher J Detzel,1 Gerald L Klein,4 Timothy P Bradshaw1

1Clinical Development, Entera Health, Inc., 2Life Sciences Consulting and Analytics, EarlyPhase Sciences, Inc., Cary, 3Executive Management, Prairie Pharms, LLC, Nora Springs, 4Executive Management, MedSurgPI, LLC, Raleigh, NC, USA

Purpose: Previous studies have shown that oral administration of bovine immunoglobulin protein preparations is safe and provides nutritional and intestinal health benefits. The purpose of this study was to evaluate the plasma amino acid response following a single dose of serum-derived bovine immunoglobulin/protein isolate (SBI) and whether bovine immunoglobulin G (IgG) is present in stool or in blood following multiple doses of SBI in healthy volunteers.
Methods: A total of 42 healthy adults were administered…


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