Certain Antidepressants May Up Risk of Intracranial Hemorrhage – Monthly Prescribing Reference (registration)

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December 05, 2016

Researchers evaluated the risk for intracranial hemorrhage with the use of SSRIs vs. tricyclic antidepressants

A new study published in JAMA Neurology reports that treatment with selective serotonin reuptake inhibitors (SSRIs) and antidepressants in general with strong inhibition of serotonin reuptake is associated with a greater risk of intracranial hemorrhage.

SSRIs have been previously linked to an increase in intracranial hemorrhage, however, whether antidepressants that are strong inhibitors of serotonin reuptake actually raise the risk for intracranial hemorrhage is still unknown. 

Researchers from the Jewish General Hospital and McGill University set out to evaluate the risk for intracranial hemorrhage with the use of SSRIs vs. tricyclic antidepressants (TCAs) among new users….

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